Nottingham, February 2016
"In vitro degradation and mechanical properties of PLA-PCL copolymer unit cell scaffolds generated by two-photon polymerization" is a scientific paper published by R. M. Felfel (UNOTT) on the mechanical and degradation properties of InnovaBone biomaterials.
This study was performed at the University of Nottingham and its results show that InnovaBone scaffolds have great potential for use in tissue engineering and regenerative medicine applications.
Three-dimensional porous scaffolds were manufactured via a TPP technology based on a Schwarz Primitive minimal surface derived unit cells with μm resolution and pore size of about 300 μm. For commercialization, the writing time is still the main limitation. Nevertheless, the technology is constantly improving and recent approaches managed to create scaffolds bigger than 15 mm3 and offer encouraging preclinical results. Changes in thermal, degradation and mechanical properties of all scaffolds were related to their chemical composition (LA/CL ratio) and accelerated degradation was predictable as the rate of mass loss for all scaffolds increased gradually by increasing degradation temperature from 37 to 65 °C. The activation energies for degradation were independent of chain length and composition. By applying a temperature superposition, a feasible accelerated method was generated to predict long-term degradation time for LC scaffolds at 37 °C. These materials have the potential to replace state-of-the art implants and allografts as they can offer slower degradation and softer mechanics and avoid the acidity-burst at degradation compared to LA, and they will be translated into biological testing to determine the effect of CL on osteogenesis.